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Quantitative profiling of human brain organoid cell diversity across four protocols and multiple cell lines

Summary: Human brain organoids are powerful in vitro models for brain development and disease. However, protocol and pluripotent cell line choices influence organoid variability and cell-type representation, complicating their use in biomedical research. Here, we systematically analyze the cellular...

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Autores principales: Julia Naas, Meritxell Balmaña, Laurenz Holcik, Maria Novatchkova, Lina Dobnikar, Thomas Krausgruber, Sabrina Ladstätter, Christoph Bock, Arndt von Haeseler, Christopher Esk, Jürgen A. Knoblich
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2025-09-01
Colección:Cell Reports
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Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2211124725009398
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