Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice

Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive. Methods: To determine the role of SIRT3 in osteoclast mitoc...

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Hlavní autoři:	Kimberly K. Richardson, Gareeballah Osman Adam, Wen Ling, Aaron Warren, Adriana Marques-Carvalho, Jeff D. Thostenson, Kimberly Krager, Nukhet Aykin-Burns, Stephanie D. Byrum, Maria Almeida, Ha-Neui Kim
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-10-01
Edice:	Molecular Metabolism
Témata:	SIRT3 Mitochondria Osteoclasts Aging Acetylation Proteomics
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2212877824001431
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