Chromatin accessibility of circulating CD8⁺ T cells differentiates disease severity in IgA nephropathy

Abstract Immunoglobulin A (IgA) nephropathy (IgAN) is a prevalent primary glomerulonephritis with progressive potential. Early identification of high-risk patients is critical; however, current clinical and pathological markers are limited. This study aimed to identify epigenetic biomarkers in circu...

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Hlavní autoři:	Gwanghun Kim, Soojin Lee, Suk-Kyung Shin, Sehoon Park, Jung Hun Koh, Semin Cho, Yaerim Kim, Ik Soo Kim, Seung Jae Lee, Chaehwa Seo, Dong-Sup Lee, Hang-Rae Kim, Hyun Mu Shin, Dong Ki Kim, KORNERSTONE investigators
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-12-01
Edice:	Scientific Reports
Témata:	IgA Nephropathy CD8⁺ T cells Chromatin accessibility Biomarkers Chronic kidney disease
On-line přístup:	https://doi.org/10.1038/s41598-025-31213-9
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