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Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate.

Protein conformational diseases are characterized by misfolding and toxic aggregation of metastable proteins, often culminating in neurodegeneration. Enteric bacteria influence the pathogenesis of neurodegenerative diseases; however, the complexity of the human microbiome hinders our understanding o...

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Huvudupphov: Alyssa C Walker, Rohan Bhargava, Alfonso S Vaziriyan-Sani, Christine Pourciau, Emily T Donahue, Autumn S Dove, Michael J Gebhardt, Garrett L Ellward, Tony Romeo, Daniel M Czyż
Materialtyp: Artigo
Språk:Inglês
Utgiven: Public Library of Science (PLoS) 2021-05-01
Serie:PLoS Pathogens
Länkar:https://doi.org/10.1371/journal.ppat.1009510
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