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Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity

Summary: Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an unmet need. Photopharmacology can address this con...

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Asıl Yazarlar: Silvia Panarello, Aleix González-Díez, Alice E. Berizzi, Fanny Malhaire, Roser Borràs-Tudurí, Xavier Rovira, Carme Serra, Laurent Prézeau, Jean-Philippe Pin, Cyril Goudet, Amadeu Llebaria, Xavier Gómez-Santacana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2024-06-01
Seri Bilgileri:iScience
Konular:
pharmacology
natural sciences
biological sciences
Biochemistry
molecular biology
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2589004224013488
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