Single-cell multi-omics analysis reveals cellular subpopulations associated with relapse in high-risk B-ALL following intensified chemotherapy

IntroductionAcute lymphoblastic leukemia (ALL) is the most prevalent malignant tumor in children, with B-cell ALL (B-ALL) accounting for 85% of cases. Despite advancements in chemotherapy and supportive care, a subset of high-risk B-ALL patients still experience relapse post-treatment. The molecular...

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Autores principales:	Li Liu, Xiaoyan Mao, Chunhui Yang, Na Li, Yan Zhou, Li Zhang, Nanjing Jiang, Yu Huang, Shigang Yin, Huangfan Xie, Xin Tian
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-11-01
Colección:	Frontiers in Immunology
Materias:	high-risk B-ALL scRNA-seq scATAC-seq PBMCs CNV
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1645546/full
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