Safety and efficacy of esketamine combined with propofol or ciprofol sedation for electroconvulsive therapy in patients with major depressive disorder: protocol for a randomized, double-blind, controlled trial with factorial design

IntroductionElectroconvulsive therapy (ECT) is one of the main strategies for major depressive disorder (MDD). Recently, the use of esketamine in the treatment of depression due to the rapid antidepressant effects has been highlighted. The present study hypothesizes that 1) adjunctive esketamine dur...

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Principais autores:	Yuan Zhang, De-zhen Su, Rong Chen, Zhong-yuan Xia, Yan-ling Peng, Shen-hong Weng, Qing-tao Meng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
coleção:	Frontiers in Pharmacology
Assuntos:	esketamine propofol ciprofol major depressive disorder ECT
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1622672/full
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