Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity

Summary: An important but still enigmatic function of DNA:RNA hybrids is their role in DNA double-strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the human helicase Senataxin, is recruited at an HO endonuclease-induced DSB and limits the local accumulation of DNA:RN...

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Autors principals:	Chetan C. Rawal, Luca Zardoni, Matteo Di Terlizzi, Elena Galati, Alessandra Brambati, Federico Lazzaro, Giordano Liberi, Achille Pellicioli
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2020-05-01
Col·lecció:	Cell Reports
Matèries:	DSB resection DSB repair Sen1/Senataxin DNA:RNA hybrid Mre11 Dna2
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124720305520
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