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Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis

The nature and longevity of the T-cell response directed against Mycobacterium tuberculosis (MTB) are important for effective pathogen containment. We analyzed ex vivo the nature of MTB antigen-specific T-cell responses directed against the MTB secreted antigens Rv0288, Rv1886c, Rv3875, the antigens...

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Principais autores: Rebecca Axelsson-Robertson, Ji Hyeon Ju, Ho-Youn Kim, Alimuddin Zumla, Markus Maeurer
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015-03-01
coleção:International Journal of Infectious Diseases
Assuntos:
CD8+ T-cells
Mycobacterium tuberculosis
T-cell differentiation
Tetramer
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1201971214017342
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