Macrophage MMP10 Regulates TLR7-Mediated Tolerance
Using an in vivo model of tolerance to TLR7-induced skin inflammation, we found a critical role for macrophage-derived MMP10 in mediating immune hypo-responsiveness. Cutaneous exposure to Imiquimod (IMQ), a TLR7 agonist, induced acute expression of pro-inflammatory factors (IL1β, IL6, CXCL1) and neu...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Frontiers Media S.A.
2018-12-01
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| Colección: | Frontiers in Immunology |
| Materias: | |
| Acceso en línea: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02817/full |
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