Randomized field trial of a therapeutic vaccine against Trypanosoma cruzi natural infection in dogs and correlates for efficacy

Abstract Chagas disease, caused by Trypanosoma cruzi, is a vector-borne parasitic disease, and dogs are a major domestic host of the parasite. We performed the first randomized field trial of an immunotherapeutic vaccine among client-owned dogs with natural infections and investigated immune correla...

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Autori principali:	Jorge A. Calderón-Quintal, Christian F. Teh-Poot, Landy M. Pech-Pisté, Pedro P. Martinez-Vega, Victor Dzul-Huchim, Juan Felipe Torres-Acosta, Etienne Waleckx, Liliana Villanueva-Lizama, Jaime Ortega-Lopez, Claudia Herrera, Eric Dumonteil, Julio Vladimir Cruz-Chan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-12-01
Serie:	npj Vaccines
Accesso online:	https://doi.org/10.1038/s41541-025-01338-z
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