Drug-specific risks of acute kidney injury associated with triple whammy therapy: a nationwide self-controlled case series study in Japan

Abstract Background Concomitant use of renin–angiotensin system inhibitors (RASIs), diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs), commonly referred to as the “triple whammy” (TW), is known to increase the risk of acute kidney injury (AKI). However, the relative contribution of each d...

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Autori principali:	Yuki Kunitsu, Rina Abe, Keiko Ikuta, Daiki Hira, Shunsaku Nakagawa, Masahiro Tsuda, Tomohiro Terada
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-03-01
Serie:	Journal of Pharmaceutical Health Care and Sciences
Soggetti:	Acute kidney injury Non-steroidal anti-inflammatory drugs Renin-angiotensin system inhibitors Diuretics Triple whammy Self-controlled case series
Accesso online:	https://doi.org/10.1186/s40780-026-00560-8
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