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Maladaptation of dentate gyrus mossy cells mediates contextual discrimination deficit after traumatic stress

Summary: Fear overgeneralization is a maladaptive response to traumatic stress that is associated with the inability to discriminate between threat and safety contexts, a hallmark feature of post-traumatic stress disorder (PTSD). However, the neural mechanisms underlying this deficit remain unclear....

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Hauptverfasser: Minseok Jeong, Jin-Hyeok Jang, Seo-Jin Oh, Jeongrak Park, Junseop Lee, Sehyeon Hwang, Yong-Seok Oh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-04-01
Schriftenreihe:Cell Reports
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Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124724003280
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