Coxsackievirus A10 blocks autophagosome-lysosome fusion to promote viral nonlytic spread and inflammatory cytokine release

ABSTRACT We aimed to demonstrate whether coxsackievirus A10 (CV-A10) perturbed the fusion between autophagosomes and lysosomes to cause viral nonlytic spread and inflammatory cytokine release at the blood-brain barrier (BBB), thereby contributing to neuropathological damage. CV-A10-induced autophagi...

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Autori principali:	Ruibin Wang, Hui Li, Lin Zhu, Yuping Zhang, Rongxia Zuo, Chen Liu, Jie Song, Yajie Hu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-12-01
Serie:	Microbiology Spectrum
Soggetti:	coxsackievirus A10 (CV-A10) autophagic secretory pathway nonlytic viral spread inflammatory cytokine release neuropathological complications
Accesso online:	https://journals.asm.org/doi/10.1128/spectrum.00830-25
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