CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation

IKKα is an NSCLC suppressor and its loss in mouse AT-II lung epithelial cells or in human NSCLC lines increased urethane-induced adenoma growth and xenograft burdens, respectively. IKKα loss can up-regulate HIF-1α, enhancing tumor growth under hypoxia. Through the progressive accumulation of genetic...

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Detalhes bibliográficos

Principais autores:	Evangelia Chavdoula, David M Habiel, Eugenia Roupakia, Georgios S Markopoulos, Eleni Vasilaki, Antonis Kokkalis, Alexander P Polyzos, Haralabia Boleti, Dimitris Thanos, Apostolos Klinakis, Evangelos Kolettas, Kenneth B Marcu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Life Science Alliance LLC 2019-12-01
coleção:	Life Science Alliance
Acesso em linha:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201900460
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