EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors

Introduction: The EGFR-A763_Y764insFQEA is a unique exon 20 insertion mutation (∼5% to 6% of exon 20 insertions), which, at the structural and enzyme kinetic level, more closely resembles EGFR tyrosine kinase inhibitor (TKI)–sensitizing mutants, such as EGFR exon 19 indels and L858R. A limited numbe...

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Hlavní autoři:	Pedro E.N.S. Vasconcelos, MS, Carol Gergis, MS, Hollis Viray, MD, Andreas Varkaris, MD, PhD, Masanori Fujii, MD, PhD, Deepa Rangachari, MD, Paul A. VanderLaan, MD, PhD, Ikei S. Kobayashi, MD, PhD, Susumu S. Kobayashi, MD, PhD, Daniel B. Costa, MD, PhD
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2020-09-01
Edice:	JTO Clinical and Research Reports
Témata:	Lung cancer EGFR exon 20 insertion A763_Y764insFQEA Kinase inhibitor Osimertinib Mobocertinib
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666364320300564
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