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Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic agent capable of infecting humans and a wide range of animal species. Over the duration of the pandemic, mutations in the SARS-CoV-2 spike (S) protein have arisen, culminating in the spread of several variants of con...

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Principais autores: Yunjeong Kim, Natasha N. Gaudreault, David A. Meekins, Krishani D. Perera, Dashzeveg Bold, Jessie D. Trujillo, Igor Morozov, Chester D. McDowell, Kyeong-Ok Chang, Juergen A. Richt
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2022-06-01
Serier:Microbiology Spectrum
Fag:
SARS-CoV-2
variants of concern
spike mutations
virus entry
virus replication
neutralization
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.01789-21
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