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TRYPTOPHAN AND INDOLEAMINE-2,3-DIOXYGENASE (IDO) IN PATHOGENESIS OF IMMUNOSUPPRESSIVE CLINICAL CONDITIONS

Increasing amounts of literature data suggest the leading role of indoleamine 2,3-deoxygenase (IDO) enzyme in regulation of immunosuppressive mechanisms. IDO is produced, mostly, by dendritic cells, being induced, e.g., under IFNγ involvement. Its function is to provide catabolism of tryptophan, an...

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Autori principali: V. A. Kozlov, D. V. Demina
Natura: Artigo
Lingua:Russo
Pubblicazione: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2017-07-01
Serie:Медицинская иммунология
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Accesso online:https://www.mimmun.ru/mimmun/article/view/1257
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