Inefficacy of dexamethasone and pirfenidone as comparators in the bleomycin-induced pulmonary fibrosis model in SD rats

BackgroundPulmonary fibrosis (PF) is a severe disease leading to disability and death. It is important to search for novel therapeutic agents, for which a model of bleomycin-induced PF is used and pirfenidone and dexamethasone are used as comparators. The aim of the study was to establish the effect...

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Hauptverfasser:	Elena A. Tukhovskaya, Yulia A. Palikova, Maria S. Severyukhina, Alina M. Ismailova, Victor A. Palikov, Gulsara A. Slashcheva, Natalya A. Borozdina, Evgeniy S. Mikhaylov, Irina N. Kravchenko, Vitaly A. Kazakov, Ekaterina N. Kazakova, Elena A. Kalabina, Ekaterina A. Rasskazova, Maksim V. Shinelev, Elena S. Sadovnikova, Natalia F. Perepechenova, Vladimir A. Rykov, Karina A. Ivanova, Anna A. Kudriaeva, Alexander A. Globenko, Andrey S. Kolosov, Ekaterina A. Jain, Olga I. Patsap, Michael A. Ignatyuk, Alexey A. Belogurov, Arkady N. Murashev
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-05-01
Schriftenreihe:	Frontiers in Medicine
Schlagworte:	bleomycine comparator drugs dexamethasone pirfenidone pulmonary fibrosis model rats
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmed.2026.1822289/full
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