HER2 quantitative continuous scoring for accurate patient selection in HER2 negative trastuzumab deruxtecan treated breast cancer

Abstract Many targeted cancer therapies rely on biomarkers assessed by scoring of immunohistochemically (IHC)-stained tissue, which is subjective, semiquantitative, and does not account for expression heterogeneity. We describe an image analysis-based method for quantitative continuous scoring (QCS)...

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Hlavní autoři:	Ansh Kapil, Andreas Spitzmüller, Nicolas Brieu, Susanne Haneder, Anatoliy Shumilov, Armin Meier, Fabiola Cecchi, Alice Barkell, Nathalie Harder, Katrin Mittermaier, Ana Hidalgo-Sastre, Regina Alleze, Markus Schick, Günter Schmidt, Hadassah Sade, Zenta Tsuchihashi, Fumitaka Suto, Mark Gustavson, J. Carl Barrett, Danielle Carroll
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-05-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-024-61957-9
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