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Sex differences in the skeletal muscle response to metformin treatment and the possible association with gut-muscle axis in rats

IntroductionMetformin (MT) is widely used in treating type 2 diabetes, and muscle is one of the targets for MT action. Recent studies have shown that gut microbiota plays a key role in mediating the clinical effects of MT, as well as affects muscle function, through the gut-muscle axis. However, it...

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Principais autores: Lin Song, Rui Wang, Jiaqi Cui, Shuyuan Hu, Jingyue Wang, Jiaming Xie, Pudan Miao, Bo Sun
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-09-01
Serier:Frontiers in Endocrinology
Fag:
metformin
muscle
gut microbiota
short chain fatty acid
sex differences
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2025.1650805/full
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