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A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1G93A Rats

Abstract An increasing number of studies have demonstrated the beneficial effects of human mesenchymal stem cells (hMSC) in the treatment of amyotrophic lateral sclerosis (ALS). We compared the effect of repeated intrathecal applications of hMSC or their conditioned medium (CondM) using lumbar punct...

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Principais autores: Monika Řehořová, Ingrid Vargová, Serhiy Forostyak, Irena Vacková, Karolína Turnovcová, Helena Kupcová Skalníková, Petr Vodička, Šárka Kubinová, Eva Syková, Pavla Jendelová
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019-06-01
coleção:Stem Cells Translational Medicine
Assuntos:
Amyotrophic lateral sclerosis
Mesenchymal stem cells
Necroptosis
Apoptosis
Autophagy
Acesso em linha:https://doi.org/10.1002/sctm.18-0223
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