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Thonningianin A derived from Penthorum chinense Pursh alleviates cerebral ischemia/reperfusion-mediated apoptosis and pyroptosis through the activation of PINK1/Parkin-dependent mitophagy

Abstract Background Cerebral ischemia/reperfusion injury (CI/RI) remains a critical barrier to effective ischemic stroke (IS) treatment. While mitophagy activation has been shown to attenuate apoptosis and pyroptosis, thereby ameliorating CI/RI, the therapeutic potential of natural compounds targeti...

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Principais autores: Qianfang Yao, Guishan Hu, Can Yin, Anguo Wu, Guangqiang Hu, Dalian Qin, Xiaogang Zhou, Betty Yuen-Kwan Law, Xi Du, Li Chen, Jianqiao Li, Hong Lin, Xin Long, Jianming Wu, Lu Yu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
coleção:Chinese Medicine
Assuntos:
Cerebral ischemia/reperfusion injury
Apoptosis
Pyroptosis
Autophagy
Mitophagy
PINK1/Parkin signaling pathway
Acesso em linha:https://doi.org/10.1186/s13020-025-01247-2
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