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Thymelaea hirsuta (L.) Endl. extract attenuates NLRP3 inflammasome activation via modulation of ATPase activity

BackgroundThe NLRP3 inflammasome is a multiprotein complex of the innate immune system that mediates the maturation and secretion of interleukin-1β (IL-1β) and plays a pivotal role in the pathogenesis of chronic inflammatory diseases, including asthma, metabolic disorders, and autoimmune diseases. H...

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Principais autores: Seongjong Lee, Seoyeon Jang, Hangyeol Lee, Ali Khorchani, Abdelhamid Khaldi, Mi Jin Lee, Dong Keun Yi, Soo-Yong Kim, Sangho Choi, Hyungseok Seo, Man S. Kim, Jin Hyub Paik, Hyung Won Ryu, Yoonsung Lee, Yong Hwan Park
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-04-01
coleção:Frontiers in Pharmacology
Assuntos:
apoptosis-associated speck-like protein containing a CARD
caspase-1
interleukin-1β
NLRP3 inflammasome
Thymelaea hirsuta (L.) Endl
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2026.1781860/full
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