Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models

Rationale: Low-voltage-activated or T-type Ca2+ channels play a key role in the generation of seizures in absence epilepsy. We have described a homozygous, gain of function substitution mutation (R1584P) in the CaV3.2 T-type Ca2+ channel gene (Cacna1h) in the Genetic Absence Epilepsy Rats from Stras...

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Bibliografiska uppgifter

Huvudupphov:	Pablo M. Casillas-Espinosa, Runxuan Lin, Rui Li, Nanditha M. Nandakumar, Georgia Dawson, Emma L. Braine, Benoît Martin, Kim L. Powell, Terence J. O'Brien
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2023-08-01
Serie:	Neurobiology of Disease
Ämnen:	GAERS Absence epilepsy NEC EEG Genetic absence epilepsy of Strasbourg
Länkar:	http://www.sciencedirect.com/science/article/pii/S0969996123002322
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