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Elevated GRO-α and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia

Abstract Neuroinflammation is a hallmark of frontotemporal dementia (FTD), a heterogeneous group of proteinopathies characterized by the progressive degeneration of the frontal and temporal lobes. It is marked by microglial activation and subsequent cytokine release. Although cytokine levels in FTD...

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Autors principals: Hiu Chuen Lok, Jared S. Katzeff, John R. Hodges, Olivier Piguet, YuHong Fu, Glenda M. Halliday, Woojin Scott Kim
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2023-06-01
Col·lecció:Scientific Reports
Accés en línia:https://doi.org/10.1038/s41598-023-35945-4
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