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In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme

Glioblastoma is an aggressive tumor with poor survival rates. Bispecific T cell engagers (BTEs) against different cancers are in various stages of clinical development. Toxicity resulting from cytokine release syndrome and the short half-life of BTEs, which necessitates continuous infusion, complica...

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Principais autores: Pratik S. Bhojnagarwala, Ryan P. O’Connell, Daniel Park, Kevin Liaw, Ali R. Ali, Devivasha Bordoloi, Joel Cassel, Nicholas J. Tursi, Ebony Gary, David B. Weiner
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-09-01
Serier:Molecular Therapy: Oncolytics
Fag:
bispecific antibody
immunotherapy
glioblastoma
DNA medicine
IL-13Rα2
T cells
Online adgang:http://www.sciencedirect.com/science/article/pii/S2372770522000924
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