An Ancient Pseudoknot in TNF-α Pre-mRNA Activates PKR, Inducing eIF2α Phosphorylation that Potently Enhances Splicing

Tumor necrosis factor alpha (TNF-α) is expressed promptly during inflammatory responses. Efficient TNF-α mRNA splicing is achieved through a 3′ UTR element that activates RNA-dependent eIF2α protein kinase (PKR). The TNF-α RNA activator, we show, folds into a pseudoknot conserved from teleost fish t...

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Váldodahkkit:	Lise Sarah Namer, Farhat Osman, Yona Banai, Benoît Masquida, Rodrigo Jung, Raymond Kaempfer
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2017-07-01
Ráidu:	Cell Reports
Fáttát:	inflammatory response tumor necrosis factor regulation of mRNA splicing integrated cellular stress response stress kinase PKR translation initiation factor eIF2 eIF2α phosphorylation RNA activator of PKR RNA pseudoknot phylogenetic conservation of RNA structure
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2211124717308495
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