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Prognostic Significance of Microvessel Density and Hypoxic Markers in Canine Osteosarcoma: Insights into Angiogenesis and Tumor Aggressiveness

Canine osteosarcoma (OSA) is an aggressive and highly malignant tumor of bone with a poor prognosis and it mirrors the disease in humans. Angiogenesis, the formation of new blood vessels, is driven by hypoxia-induced factors such as HIF-1α and VEGF, both of which play a crucial role in tumor growth...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Cecilia Gola, Marcella Massimini, Emanuela Morello, Lorella Maniscalco, Luiza Cesar Conti, Mariarita Romanucci, Matteo Olimpo, Leonardo Della Salda, Raffaella De Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2024-11-01
Schriftenreihe:Animals
Schlagworte:
canine osteosarcoma
hypoxia
angiogenesis
microvessel density
immunohistochemistry
biomarkers
Online-Zugang:https://www.mdpi.com/2076-2615/14/22/3181
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