Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
Abstract: The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that Hhex maintains leukemia stem cell self-renewal by enabling Polycomb-mediated epigenetic repression of...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018-02-01
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| coleção: | Blood Advances |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2473952920310867 |
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