Pigment epithelium-derived factor protects retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction

AIM: To investigate the potential of pigment epithelium-derived factor (PEDF) to protect the immortalized rat retinal ganglion cells-5 (RGC-5) exposed to CoCl2-induced chemical hypoxia. METHODS: After being differentiated with staurosporine (SS), RGC-5 cells were cultured in four conditions: contro...

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Autors principals:	Shu-Wei Tian, Yuan Ren, Jin-Zhi Pei, Bai-Chao Ren, Yuan He
Format:	Artigo
Idioma:	Inglês
Publicat:	Press of International Journal of Ophthalmology (IJO PRESS) 2017-07-01
Col·lecció:	International Journal of Ophthalmology
Matèries:	1054 pigment epithelium-derived factor CoCl2 retinal ganglion cells-5 reactive oxygen species reduced glutathione hormone mitochondrial permeability transition pores membrane potential adenosine triphosphate Cyt C apoptosis-inducing factor
Accés en línia:	http://www.ijo.cn/en_publish/2017/7/20170705.pdf
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