Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage

Abstract Influenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown. By integrating the plasma proteomics data of the IAV-infected patients into the viral-inflammation protei...

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Autors principals:	Yang Yue, Qingyu Li, Changguo Chen, Juntao Yang, Weian Song, Changdong Zhou, Yuke Cui, Zhenqiao Wei, Qi He, Chenhui Wang, Hongjun Lin, Jiangbo Li, Jian Li, Ji Xi, Xiang Song, Wen Yang, Ze Zhang, Wenjie Shu, Liang Guo, Shengqi Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2025-06-01
Col·lecció:	Signal Transduction and Targeted Therapy
Accés en línia:	https://doi.org/10.1038/s41392-025-02272-1
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