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A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the StomachSummary

Background & Aims: RUNX transcription factors play pivotal roles in embryonic development and neoplasia. We previously identified the single missense mutation R122C in RUNX3 from human gastric cancer. However, how RUNX3R122C mutation disrupts stem cell homeostasis and promotes gastric carcinogen...

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Автори: Daisuke Douchi, Akihiro Yamamura, Junichi Matsuo, Jung-Won Lee, Napat Nuttonmanit, Yi Hui Melissa Lim, Kazuto Suda, Mitsuhiro Shimura, Sabirah Chen, ShuChin Pang, Kazuyoshi Kohu, Mari Kaneko, Hiroshi Kiyonari, Atsushi Kaneda, Hideyuki Yoshida, Ichiro Taniuchi, Motomi Osato, Henry Yang, Michiaki Unno, Jimmy Bok-Yan So, Khay Guan Yeoh, Linda Shyue Huey Chuang, Suk-Chul Bae, Yoshiaki Ito
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2022-01-01
Серія:Cellular and Molecular Gastroenterology and Hepatology
Предмети:
Isthmus
Stem/Progenitor Cell
Enhanced Stem Cell Activity
Preneoplastic State
Gastric Carcinogenesis
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2352345X22000108
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