Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development

Possible distinct contributions of Runx 2 and Runx3 in osteoarthritis have not been clarified. Nagata et al. show that Runx3 protects adult articular cartilage by extracellular matrix protein production in normal conditions, while Runx2 exerts both catabolic and anabolic effects during inflammation.

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Kosei Nagata, Hironori Hojo, Song Ho Chang, Hiroyuki Okada, Fumiko Yano, Ryota Chijimatsu, Yasunori Omata, Daisuke Mori, Yuma Makii, Manabu Kawata, Taizo Kaneko, Yasuhide Iwanaga, Hideki Nakamoto, Yuji Maenohara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuki Taniguchi, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Nature Portfolio 2022-10-01
سلاسل:	Nature Communications
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41467-022-33744-5
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!