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Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral tropism and biodistribution, and can lead to potent...

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Hlavní autoři: Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2023-06-01
Edice:Viruses
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On-line přístup:https://www.mdpi.com/1999-4915/15/6/1343
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