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Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

Objective: The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve glucose tolerance in mice on chow or high-fat diet (...

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Príomhchruthaitheoirí: Tulika Arora, Udo Wegmann, Anup Bobhate, Ying Shiuan Lee, Thomas U. Greiner, Daniel J. Drucker, Arjan Narbad, Fredrik Bäckhed
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2016-08-01
Sraith:Molecular Metabolism
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2212877816300692
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