Enhanced treatment of breast cancer brain metastases with oncolytic virus expressing anti-CD47 antibody and temozolomide

Limited therapeutic options are available for patients with breast cancer brain metastases (BCBM), and thus there is an urgent need for novel treatment approaches. We previously engineered an effective oncolytic herpes simplex virus 1 (oHSV) expressing a full-length anti-CD47 monoclonal antibody (mA...

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Bibliographic Details

Main Authors:	Jing Wang, Lei Tian, Tasha Barr, Lewei Jin, Yuqing Chen, Zhiyao Li, Ge Wang, Jian-Chang Liu, Li-Shu Wang, Jianying Zhang, David Hsu, Mingye Feng, Michael A. Caligiuri, Jianhua Yu
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2024-09-01
Series:	Molecular Therapy: Oncology
Subjects:	tumor microenvironment oncolytic herpes simplex virus temozolomide TMZ breast cancer brain metastases CD47
Online Access:	http://www.sciencedirect.com/science/article/pii/S2950329924000663
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