Altered intestinal barrier contributes to cognitive impairment in old mice with constipation after sevoflurane anesthesia

BackgroundElderly patients have a high risk of developing postoperative cognitive dysfunction (POCD). Gastrointestinal disorders, such as constipation, in the elderly population may be involved in the pathogenesis of neurological disorders by promoting inflammatory responses due to a ‘leaky gut’. Ge...

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Hlavní autoři:	Tianyun Zhao, Junming Lu, Jingwen Qin, Yanxin Chen, Ziwen Shi, Wei Wei, Peng Xiong, Daqing Ma, Xingrong Song
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-09-01
Edice:	Frontiers in Nutrition
Témata:	perioperative neurocognitive dysfunction gastrointestinal dysfunction slow transit constipation gut permeability microglia
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnut.2023.1117028/full
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