A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation

Abstract Cereblon (CRBN) is an E3 ubiquitin ligase widely harnessed for targeted protein degradation (TPD). We report the discovery of a molecular glue degrader (MGD), MRT-31619, that drives homo-dimerization of CRBN and promotes its fast, potent, and selective degradation by the ubiquitin proteasom...

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Principais autores:	Gerasimos Langousis, Pablo Gainza, Moritz Hunkeler, Despoina Kapsitidou, Etienne J. Donckele, Stefano Annunziato, Lars Wiedmer, Katherine F. M. Jones, Bradley DeMarco, Chao Quan, Richard D. Bunker, Kevin J. Lumb, Bernhard Fasching, John C. Castle, Sharon A. Townson, Débora Bonenfant
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-11-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-025-65094-3
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