Familial hemophagocytic lymphohistiocytosis hepatitis is mediated by IFN-γ in a predominantly hepatic-intrinsic manner

Interferon gamma (IFN-γ) is the main cytokine driving organ dysfunction in Familial Hemophagocytic Lymphohistiocytosis (FHL). Blockade of IFN-γ pathway ameliorates FHL hepatitis, both in animal models and in humans with FHL. Hepatocytes are known to express IFN-γ receptor (IFN-γ-R). However, whether...

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Detalhes bibliográficos

Principais autores:	Tamir Diamond, Thomas N. Burn, Mailyn A. Nishiguchi, Danielle Minichino, Julie Chase, Niansheng Chu, Portia A. Kreiger, Edward M. Behrens
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2022-01-01
coleção:	PLoS ONE
Acesso em linha:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173616/?tool=EBI
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