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Contactin-2 protects against aortic valve calcification via osteogenic differentiation inhibition

Abstract Current pharmacological strategies for delaying the progression of calcific aortic valve disease (CAVD) remain inadequate. This study used Mendelian randomization (MR) analysis to identify a significant association between the plasma protein Contactin-2 (CNTN2) and CAVD. Transcriptomic and...

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Principais autores: Zhongxing Zhou, Ruming Shen, Shuaijie Chen, Hailin Zhang, Longqing Chen, Xiuzhu Weng, Xiaoyan Lin, Dajun Chai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-03-01
coleção:Scientific Reports
Assuntos:
Contactin-2
Calcific aortic valve disease
Valve interstitial cells
Osteogenic differentiation
Mendelian randomization
Acesso em linha:https://doi.org/10.1038/s41598-026-42767-7
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