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Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity

BackgroundPrevious reports identified proteins associated with ‘apoptosis’ following cross-linking PrPC with motif-specific anti-PrP antibodies in vivo and in vitro. The molecular mechanisms underlying this IgG-mediated neurotoxicity and the role of the activated proteins in the apoptotic pathways l...

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Hoofdauteurs: Utpal Kumar Adhikari, Elif Sakiz, Xian Zhou, Umma Habiba, Sachin Kumar, Meena Mikhael, Matteo Senesi, Chun Guang Li, Gilles J. Guillemin, Lezanne Ooi, Monique Antoinette David, Steven Collins, Tim Karl, Mourad Tayebi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021-07-01
Reeks:Frontiers in Immunology
Onderwerpen:
anti-PrP antibodies
cellular prion protein
neurotoxicity
allergenicity
mouse primary neurons
neuroblastoma cell line
Online toegang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.639008/full
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