DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions

Abstract DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage. While DDR promotes genomic stability in normal cells, it also protects cancer cells from DNA l...

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Detalhes bibliográficos

Principais autores:	Tianen Chen, Suparat Tongpeng, Ziyi Lu, Win Topatana, Sarun Juengpanich, Shijie Li, Jiahao Hu, Jiasheng Cao, Cheeshin Lee, Yitong Tian, Mingyu Chen, Xiujun Cai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2022-03-01
coleção:	Aging and Cancer
Assuntos:	cancer therapy combination therapy DNA damage response DNA damage response inhibitors DNA repair PARP inhibitors
Acesso em linha:	https://doi.org/10.1002/aac2.12047
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