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mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney

Tertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues that form de novo in nonlymphoid organs. In this study, we demonstrate that the kidneys of aged mice with a renal tubule-specific knockout of autophagy-related 7 (Atg7) contain numerous and large TLTs. p-S6 protein, a marker of mTORC1, wa...

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Principais autores: Daniel J. Atwood, Zhibin He, Makoto Miyazaki, Katharina Hopp, Alkesh Jani, Seth B. Furgeson, Sarah Faubel, Charles L. Edelstein
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-05-01
coleção:Frontiers in Immunology
Assuntos:
autophagy
mTOR
polycystic kidney
p62
tertiary lymphoid tissue
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527817/full
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