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CgAS, a gene encoding anthranilic acid synthase, contributes to tryptophan biosynthesis and enhanced chaetoglobosin A production in Chaetomium globosum W7

Chaetoglobosin A (cheA) is a complex indole alkaloid exhibiting preferential cytotoxicity against plant pathogens, parasites, and tumor cells. However, the limited production and high synthesis costs of cheA impede its widespread application. Tryptophan serves as a precursor for cheA biosynthesis, a...

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Principais autores: Shanshan Zhao, Zefei Wang, Liyan Tian, Kejing Li, Shiwei Sun, Gen Chen, Daoqiong Zheng
Formato: Artigo
Idioma:Inglês
Publicado: KeAi Communications Co., Ltd. 2025-09-01
Series:Synthetic and Systems Biotechnology
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2405805X2500064X
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