Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca2+ uptake, an important regulator of cellular ATP homeostasis. In a pathophysiological setting pharmacologica...

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Detalhes bibliográficos

Principais autores:	Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T. Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-12-01
coleção:	Frontiers in Physiology
Assuntos:	mitochondria reactive oxygen species ryanodine receptor hypertrophy ventricular arrhythmia Ca2+-induced Ca2+ release
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphys.2018.01831/full
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