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The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

Hair cells of the cochlea are mechanosensors for the perception of sound. Mutations in the LRTOMT gene, which encodes a protein with homology to the catecholamine methyltransferase COMT that is linked to schizophrenia, cause deafness. Here, we show that Tomt/Comt2, the murine ortholog of LRTOMT, has...

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Библиографические подробности
Главные авторы: Christopher L Cunningham, Zizhen Wu, Aria Jafari, Bo Zhao, Kat Schrode, Sarah Harkins-Perry, Amanda Lauer, Ulrich Müller
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications Ltd 2017-05-01
Серии:eLife
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Online-ссылка:https://elifesciences.org/articles/24318
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