One gene, many phenotypes: the role of KIF5A in neurodegenerative and neurodevelopmental diseases

Abstract Kinesin family member 5 A (KIF5A) is a neuron-specific molecular motor involved in anterograde transport. KIF5A mediates a wide range of trafficking processes that are only partially shared with the other members of the KIF5 family. Since 2002, several disease-causing mutations have been fo...

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Podrobná bibliografie

Hlavní autoři:	Marta Cozzi, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Paola Pramaggiore, Laura Cornaggia, Rocio Magdalena, Maria Brodnanova, Ali Mohamed, Carmelo Milioto, Margherita Piccolella, Mariarita Galbiati, Paola Rusmini, Valeria Crippa, Cinzia Gellera, Stefania Magri, Franco Taroni, Riccardo Cristofani, Angelo Poletti
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-06-01
Edice:	Cell Communication and Signaling
Témata:	KIF5A Hereditary spastic paraplegia Charcot-Marie-Tooth disease Amyotrophic lateral sclerosis Neonatal intractable myoclonus
On-line přístup:	https://doi.org/10.1186/s12964-025-02277-x
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