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PPARɑ variant V227A reduces plasma triglycerides through enhanced lipoprotein lipolysis

Human single nucleotide variants in peroxisome proliferator-activated receptor-ɑ (PPARɑ) have been associated with beneficial metabolic phenotypes, yet their specific effects on metabolic gene expression are not well defined. Here, we developed a mouse model of a human PPARɑ variant encoding a subst...

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Hoofdauteurs: Lauren F. Uchiyama, Gabriel P.M. Ordonez, Khoi T. Pham, John P. Kennelly, Maykel López Rodríguez, Lany Tran, Peter Tontonoz, Alexander Nguyen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2025-05-01
Reeks:Journal of Lipid Research
Onderwerpen:
lipolysis and fatty acid metabolism
lipoprotein lipase
liver
PPARs
triglycerides
Online toegang:http://www.sciencedirect.com/science/article/pii/S0022227525000665
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