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Advances in Drug Delivery Science for Diacerein: Strategies to Enhance Solubility, Bioavailability, and Pharmacokinetic Performance

Diacerein is known as a disease-modifying anti-inflammatory drug, primarily used for the treatment of osteoarthritis. Despite its therapeutic potential, the clinical use of diacerein is hindered by poor aqueous solubility, low bioavailability, liver issues, and gastrointestinal side effects, particu...

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Principais autores: Maryam Naseri, Sajjad Ghobakhlou, Niloofar Heidarizade, Mohammad Emad Akbari, Alireza Lotfabadi, Soroor Sadegh Malvajerd, Zhila Izadi, Hassan Maleki
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-11-01
Serier:Pharmaceutics
Fag:
anti-inflammatory
bioavailability
diacerein
nanocarrier
osteoarthritis
solubility
Online adgang:https://www.mdpi.com/1999-4923/17/12/1539
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